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Glucose-dependent insulinotropic peptide (GIP) is produced by duodenal K cells and GLP-1 comes from ileal L-cells and together these hormones account for 60% of the nutrient dependent insulin release

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Given the neuroprotective effects of both GLP-1 and estradiol, it would also be interesting to know how such agents might reduce neurodegeneration, especially in menopausal women

However, fitting the overall two-site curve to the standard MichaelisMenten equation yields apparent single-site parameters ( K M 7.75, V max 112.09, R 2 = 0.98), potentially leading to the erroneous conclusion that the reaction involves only one active site